International Journal of General Medicine (Feb 2021)
A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with Percutaneous Coronary Intervention
Abstract
Fang Chen,1 Jing Zhang,2 Cheng-Xue Bian,2 Jian Zhang,3 Xiang-Bin Xin,2 Yang-Yang Pan,2 Xuan Zhang2 1Department of Cardiology, Yinchuan First People’s Hospital, Yinchuan, People’s Republic of China; 2Department of Cardiology, Ningxia Medical University, Yinchuan, People’s Republic of China; 3Department of Clinical Laboratory, Yinchuan First People’s Hospital, Yinchuan, People’s Republic of ChinaCorrespondence: Fang ChenDepartment of Cardiology, Yinchuan First People’s Hospital, No. 2 of Liqun West Street, Xingqing District, Yinchuan, 750000, People’s Republic of ChinaTel +86 0951-6997179Fax +86 0951-6192355Email [email protected]: This study assesses the correlation between MDR1 gene polymorphism and clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated with percutaneous coronary intervention (PCI).Methods: The study includes 204 Ningxia Hui patients with CHD who were treated with PCI. These patients were divided into two groups: those who with CR and others were non-clopidogrel resistant (NCR), according to the results of the patients’ platelet aggregation rate, which was tested by adenosine diphosphate-induced turbidimetry on the second postoperative day. C3435T and C1236T genotypes and alleles were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: The CR rate was 24.0%, and there were 3 genotypes of C3435T and C1236T. For C3435T, the distribution frequency of the 3435TT genotype and T allele was significantly higher in the CR group than in the NCR group. For C1236T, no significant difference was found between the two groups.Conclusion: Hui patients who had CHD were treated with PCI. CR was most likely to occur in those who had the T allele of MDR1 in gene C3435T.Keywords: coronary heart disease, MDR1 gene, clopidogrel resistance, gene polymorphism, platelet aggregation rate
