Elevated lactate dehydrogenase predicts pneumonia in spontaneous intracerebral hemorrhage
Yangchun Xiao,
Shuanghong He,
Xin Cheng,
Liyuan Peng,
Yixin Tian,
Tiangui Li,
Jialing He,
Pengfei Hao,
Weelic Chong,
Yang Hai,
Chao You,
Fang Fang,
Zongjun Peng,
Yu Zhang
Affiliations
Yangchun Xiao
Department of Neurosurgery, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China
Shuanghong He
Health Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Xin Cheng
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Liyuan Peng
Department of Neurosurgery, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China
Yixin Tian
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Tiangui Li
Department of Neurosurgery, The First People's Hospital of Longquanyi District Chengdu, Sichuan, China
Jialing He
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Pengfei Hao
Department of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China
Weelic Chong
Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA
Yang Hai
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA
Chao You
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Fang Fang
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Zongjun Peng
Department of Neurosurgery, Sichuan Friendship Hospital, China
Yu Zhang
Department of Neurosurgery, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China; Corresponding author. Clinical Medical College and Affiliated Hospital of Chengdu University, 82 North Second Ring Road, Chengdu, Sichuan, 610081, China.
Background: Although a variety of risk factors for pneumonia after spontaneous intracerebral hemorrhage have been established, an objective and easily obtainable predictor is still needed. Lactate dehydrogenase is a nonspecific inflammatory biomarker. In this study, we aimed to assess the association between lactate dehydrogenase and pneumonia in spontaneous intracerebral hemorrhage patients. Methods: Our study was a retrospective, multicenter cohort study, undertaken in 7562 patients diagnosed with spontaneous intracerebral hemorrhage from 3 hospitals. All serum Lactate dehydrogenase was collected within 7 days from admission and divided into four groups as quartile(Q). We conducted a multivariable logistic regression analysis to assess the association of Lactate dehydrogenase with pneumonia. Results: Among a total of 7562 patients, 2971 (39.3%) patients were diagnosed with pneumonia. All grades of elevated lactate dehydrogenase were associated with increased raw and risk-adjusted risk of pneumonia. Multiple logistic regression analysis showed odds ratios for Q2-Q4 compared with Q1 were 1.21 (95% CI, 1.04–1.42), 1.64(95% CI, 1.41–1.92), and 1.92 (95% CI, 1.63–2.25) respectively. The odds ratio after adjustment was 4.42 (95% CI, 2.94–6.64) when lactate dehydrogenase was a continuous variable after log-transformed. Conclusions: Elevated lactate dehydrogenase is significantly associated with an increase in the odds of pneumonia and has a predictive value for severe pneumonia in patients with pneumonia. Lactate dehydrogenase may be used to predict pneumonia events in spontaneous intracerebral hemorrhage patients as a laboratory marker.
