Epithelial reticular cells of the thymus and the regulatory T-lymphocytes

Abstract

The article presents a review of the literature. The article presents the published data on the role of reticular epithelial cells in the formation of specific microenvironment in the cortex and medulla of thymic lobules. Thymic microenvironment plays a key role in T-cell differentiation. Discusses the role of medullar epithelial cells in the development of regulatory T-lymphocytes and induction of tolerance.

Keywords

• thymus
• reticular epithelial cells
• regulatory t-cells
• tolerance