Nature and Science of Sleep (Nov 2021)

Biomarkers and Dynamic Cerebral Autoregulation of Obstructive Sleep Apnea-Hypopnea Syndrome

  • Zhang Y,
  • Wu X,
  • Sun Q,
  • Tang Q,
  • Guo ZN,
  • Wang Z,
  • Yang Y

Journal volume & issue
Vol. Volume 13
pp. 2019 – 2028

Abstract

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Yanan Zhang,1 Xiaodan Wu,1 Qingqing Sun,1 Qi Tang,1 Zhen-Ni Guo,2 Zan Wang,1 Yi Yang2 1Department of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Neurology and Neuroscience Center, Clinical Trial and Research Center for Stroke, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Zan WangDepartment of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaEmail [email protected]; [email protected] YangDepartment of Neurology and Neuroscience Center, Clinical Trial and Research Center for Stroke, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaEmail [email protected]; [email protected]: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) have impaired dynamic cerebral autoregulation (dCA). This study aimed to explore whether serum levels of apolipoprotein B-100 (ApoB-100), fibronectin (FN), and ceruloplasmin (CP) were related to impaired dCA in OSAHS.Methods: A total of 90 patients with OSAHS from our database management system were enrolled and further divided into three subgroups according to the apnea-hypopnea index (AHI) using polysomnography results: mild (5 ≤ AHI ≤ 15), moderate (15 30), with 30 patients in each group. Thirty sex- and age-matched healthy controls were recruited for this study. The serum levels of ApoB-100, FN, and CP were measured by enzyme-linked immunosorbent assays. dCA was assessed by analyzing the phase difference (PD) using transfer function analysis.Results: Serum levels of ApoB-100, FN, and CP were significantly higher in the mild, moderate, and severe OSAHS groups than that in the control group (P< 0.001, respectively). The average PD of the moderate and severe OSAHS groups was lower than that of the control group (P=0.001 and P< 0.001, respectively). Receiver operating curve analysis revealed that ApoB-100, FN, and CP might be able to distinguish patients with OSAHS from healthy individuals (area under the curve = 0.959 [95% CI 0.92– 1.00], 0.987 [95% CI 0.96– 1.01], 0.982 [95% CI 0.96– 1.00]), respectively, P< 0.001). The average PD was linearly correlated with the serum levels of ApoB-100, FN, and CP in patients with OSAHS. Multivariable analysis showed that FN and arousal index in polysomnography were associated with impaired average PD (P< 0.001 and P=0.025, respectively).Conclusion: Serum levels of ApoB-100, FN, and CP increased in patients with OSAHS. dCA was compromised in patients with OSAHS and was positively correlated with ApoB-100, FN, and CP serum levels, and FN serum levels and arousal index in polysomnography were independently associated with impaired dCA.Keywords: obstructive sleep apnea-hypopnea syndrome, apolipoprotein B-100, fibronectin, ceruloplasmin, dynamic cerebral autoregulation

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