Complex non-invasive methods of investigation of the pathophysiological processes in the skin of patients with rosacea

Abstract

Goal. To develop a complex method for diagnosing rosacea by using non-invasive examination methods and study their application for assessing the treatment efficacy. Materials and methods. The authors conducted a study of 46 rosacea patients (15 male and 31 female) including 29 patients with erythematous and 17 ones with papulous subtypes of the disease. The patients underwent treatment using IPL (5-8 treatment sessions). The condition of skin vessels was assessed prior to and after treatment using dermatoscopy, laser Doppler flowmetry (LDF) and confocal laser scanning microscopy in vivo (CLSM). Results. The authors developed a complex method for diagnosing rosacea using dermatoscopy, CLSM and LDF techniques prior to and after treatment. As many as 46 patients suffering from erythematous and papulous subtypes of rosacea underwent treatment using broadband pulse light emission. The clinical efficacy of such treatment was assessed by using a set of non-invasive examination methods, and terms for new treatment courses were forecasted. Conclusion. A combination of different enables real-time assessment of the dynamics of the pathological process in the skin of patients suffering from rosacea and makes it possible to get unbiased information about the treatment efficacy and forecast terms for new treatment courses.

Keywords

• дерматоскопия. лазерная допплеровская флоуметрия (лдф)
• конфокальная лазерная сканирующая in vivo микроскопия (клсм)
• розацеа
• dermatoscopy
• laser doppler flowmetry (ldf)
• confocal laser scanning microscopy in vivo (clsm)
• rosacea