Nature Communications (Jul 2016)
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
- Yuanming Xu,
- Fang Zhao,
- Quan Qiu,
- Kun Chen,
- Juncheng Wei,
- Qingfei Kong,
- Beixue Gao,
- Johanna Melo-Cardenas,
- Bin Zhang,
- Jinping Zhang,
- Jianxun Song,
- Donna D. Zhang,
- Jianing Zhang,
- Yunping Fan,
- Huabin Li,
- Deyu Fang
Affiliations
- Yuanming Xu
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Fang Zhao
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Quan Qiu
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Kun Chen
- Department of Otolaryngology-Head and Neck Surgery, Allergy Center, Affiliated Eye and ENT Hospital, Fudan University
- Juncheng Wei
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Qingfei Kong
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Beixue Gao
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Johanna Melo-Cardenas
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Bin Zhang
- Department of Medicine-Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
- Jinping Zhang
- Institutes of Biology and Medical Sciences, Soochow University
- Jianxun Song
- Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine
- Donna D. Zhang
- Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona
- Jianing Zhang
- Department of Biochemistry, School of Life Science and Medicine, Dalian University of Technology
- Yunping Fan
- Guangdong Provincial Engineering Research Center for Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University
- Huabin Li
- Department of Otolaryngology-Head and Neck Surgery, Allergy Center, Affiliated Eye and ENT Hospital, Fudan University
- Deyu Fang
- Department of Pathology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/ncomms12073
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and contributes to pathogenesis of autoimmune disease.
