Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

Abstract

The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevated nephron numbers.