Frontiers in Psychiatry (May 2017)
Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression
- Guilhem Carle,
- Guilhem Carle,
- Guilhem Carle,
- Mehdi Touat,
- Mehdi Touat,
- Nicolas Bruno,
- Nicolas Bruno,
- Damien Galanaud,
- Damien Galanaud,
- Charles-Siegfried Peretti,
- Charles-Siegfried Peretti,
- Antoni Valero-Cabré,
- Antoni Valero-Cabré,
- Antoni Valero-Cabré,
- Antoni Valero-Cabré,
- Richard Levy,
- Richard Levy,
- Richard Levy,
- Carole Azuar,
- Carole Azuar,
- Carole Azuar
Affiliations
- Guilhem Carle
- AP-HP, Hôpital Saint-Antoine, Department of Psychiatry, Paris, France
- Guilhem Carle
- FrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France
- Guilhem Carle
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Mehdi Touat
- AP-HP, Hôpital Saint-Antoine, Department of Neurology, Paris, France
- Mehdi Touat
- Paris Sud University, Gustave Roussy, INSERM U981, Villejuif, France
- Nicolas Bruno
- AP-HP, Hôpital Saint-Antoine, Department of Psychiatry, Paris, France
- Nicolas Bruno
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Damien Galanaud
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Damien Galanaud
- AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Neuroradiology, Paris, France
- Charles-Siegfried Peretti
- AP-HP, Hôpital Saint-Antoine, Department of Psychiatry, Paris, France
- Charles-Siegfried Peretti
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Antoni Valero-Cabré
- FrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France
- Antoni Valero-Cabré
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Antoni Valero-Cabré
- Laboratory for Cerebral Dynamics Plasticity and Rehabilitation, School of Medicine, Boston University, Boston, MA, USA
- Antoni Valero-Cabré
- Cognitive Neuroscience and Information Technology Research Program, Open University of Catalonia (UOC), Barcelona, Spain
- Richard Levy
- FrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France
- Richard Levy
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Richard Levy
- AP-HP, Hôpital Saint-Antoine, Department of Neurology, Paris, France
- Carole Azuar
- FrontLab, INSERM U1127, CNRS UMR7225, IHU Translational Neurosciences, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France
- Carole Azuar
- Sorbonne Universitas Pierre et Marie Curie (UPMC) University, Paris, France
- Carole Azuar
- AP-HP, Groupe Hospitalier Pitié-Salpêtrière, National Reference Centre on Rare Dementias, Paris, France
- DOI
- https://doi.org/10.3389/fpsyt.2017.00096
- Journal volume & issue
-
Vol. 8
Abstract
The potential of repetitive transcranial magnetic stimulation (rTMS) to treat numerous neurological and psychiatric disorders has been thoroughly studied for the last two decades. Here, we report for the first time, the case of a 65-year-old woman suffering from treatment-resistant depression who developed an acute frontal lobe syndrome following eight sessions of low-frequency rTMS (LF-rTMS) to the right dorsolateral prefrontal cortex while also treated with sertraline and mianserin. The pathophysiological mechanisms underlying such an unexpected acute frontal lobe dysfunction are discussed in relation to the therapeutic use of LF-rTMS in combination with pharmacotherapy in depressed patients.
Keywords
- depression
- transcranial magnetic stimulation
- frontal syndrome
- antidepressant
- state-dependency
- executive dysfunction
