Nature Communications (Jan 2023)
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene
Abstract
Our understanding of the genetic contribution to human adiposity is incomplete, as few studies measure adiposity directly. Here, the authors impute whole-body imaging adiposity phenotypes in large biobanks, enhancing their power to discover genes driving human adiposity, and further investigate one such gene using a mouse model.