Frontiers in Immunology (Mar 2022)
High Levels of CD244 Rather Than CD160 Associate With CD8+ T-Cell Aging
- Xinyue Wang,
- Xinyue Wang,
- Xinyue Wang,
- Xinyue Wang,
- Di Wang,
- Di Wang,
- Di Wang,
- Di Wang,
- Juan Du,
- Juan Du,
- Juan Du,
- Yuqing Wei,
- Yuqing Wei,
- Yuqing Wei,
- Rui Song,
- Beibei Wang,
- Beibei Wang,
- Beibei Wang,
- Shuang Qiu,
- Bei Li,
- Leidan Zhang,
- Yongqin Zeng,
- Hongxin Zhao,
- Yaxian Kong,
- Yaxian Kong,
- Yaxian Kong,
- Yaxian Kong
Affiliations
- Xinyue Wang
- Peking University Ditan Teaching Hospital, Beijing, China
- Xinyue Wang
- Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Xinyue Wang
- Beijing Institute of Infectious Diseases, Beijing, China
- Xinyue Wang
- National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Di Wang
- Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Di Wang
- Beijing Institute of Infectious Diseases, Beijing, China
- Di Wang
- National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Di Wang
- Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Juan Du
- Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Juan Du
- Beijing Institute of Infectious Diseases, Beijing, China
- Juan Du
- National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Yuqing Wei
- Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Yuqing Wei
- Beijing Institute of Infectious Diseases, Beijing, China
- Yuqing Wei
- National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Rui Song
- Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Beibei Wang
- Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Beibei Wang
- Beijing Institute of Infectious Diseases, Beijing, China
- Beibei Wang
- National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Shuang Qiu
- Department of Laboratory, Beijing Ji Shui Tan Hospital, Beijing, China
- Bei Li
- Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Leidan Zhang
- Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Yongqin Zeng
- Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Hongxin Zhao
- Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Yaxian Kong
- Peking University Ditan Teaching Hospital, Beijing, China
- Yaxian Kong
- Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- Yaxian Kong
- Beijing Institute of Infectious Diseases, Beijing, China
- Yaxian Kong
- National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
- DOI
- https://doi.org/10.3389/fimmu.2022.853522
- Journal volume & issue
-
Vol. 13
Abstract
Aging leads to functional dysregulation of the immune system, especially T cell defects. Previous studies have shown that the accumulation of co-inhibitory molecules plays an essential role in both T cell exhaustion and aging. In the present study, we showed that CD244 and CD160 were both up-regulated on CD8+ T cells of elderly individuals. CD244+CD160- CD8+ T cells displayed the increased activity of β-GAL, higher production of cytokines, and severe metabolic disorders, which were characteristics of immune aging. Notably, the functional dysregulation associated with aging was reversed by blocking CD244 instead of CD160. Meanwhile, CD244+CD160+ CD8+ T cells exhibited features of exhaustion, including lower levels of cytokine, impaired proliferation, and intrinsic transcriptional regulation, compared to CD244+CD160- population. Collectively, our findings demonstrated that CD244 rather than CD160 acts as a prominent regulator involved in T cell aging, providing a solid therapeutic target to improve disorders and comorbidities correlated to immune system aging.
Keywords
