Protein dan vitamin D3 meningkatkan kadar fosfor maksila anak tikus putih Rattus novergicus galur Wistar dengan berat badan lahir rendah

Abstract

Protein and vitamin D3 increase the phosphorus levels of maxillary in malnourished mice pup Background: Protein deficiency during pregnancy leads to malnutrition in the newborn. One of the signs is low birth weight, which impacts bone and teeth growth problems, most probably related to vitamin D and phosphorus deficiency. Adequate protein and vitamin D3 during the nursing period increase the phosphorus level of bone related to fosfor absorption, which increases in the gut. Objective: This research was conducted to determine the effect of protein and vitamin D3 during the nursing period on increasing phosphorus levels of maxillary in prenatal malnutrition mice. Methods: Experimental study with post-test-only control group design. Thirty the Rattus novergicus Wistar strain mice were divided into five groups (n=6). The positive control group (healthy mice suckle in mother who received a standard protein diet and vitamin D3 0.36 IU/g BW/day/oral), negative control group (malnourished mice suckle in mother who received a low protein diet), and three groups of malnutrition mice suckle in mother who receives intervention standard protein diet with vitamin D3 0.36 IU/g BW/day/oral, low protein diet with vitamin D3 0,36 IU/g BW/day/oral, and a standard protein diet without vitamin D3. The parameter measured was phosphorus levels in the maxillary. Results: ANOVA test results showed significant phosphorus level differences of maxillary between groups (p<0.001), and the Post Hoc test showed differences between the control group with interventions 1, 2, and 3 groups. Conclusion: Intervention of a standard protein diet without vitamin D3 or a low protein diet with vitamin D3 0.36 IU/day/oral significantly increases the phosphorus level of maxillary in malnourished mice. However, combining a standard protein diet and vitamin D3 0.36 IU/day/oral is the most optimum for improving maxillary bone phosphorus levels in malnourished mice.

Keywords

• maxillary bone
• phosphorus level
• prenatal malnutrition
• protein
• vitamin d3