Frontiers in Endocrinology (Jan 2023)
Emerging roles and potential application of PIWI-interacting RNA in urological tumors
- Jingcheng Zhang,
- Jingcheng Zhang,
- Wentao Zhang,
- Wentao Zhang,
- Yuchao Liu,
- Yuchao Liu,
- Man Pi,
- Yufeng Jiang,
- Yufeng Jiang,
- Ailiyaer Ainiwaer,
- Ailiyaer Ainiwaer,
- Shiyu Mao,
- Shiyu Mao,
- Haotian Chen,
- Haotian Chen,
- Yuefei Ran,
- Yuefei Ran,
- Shuwen Sun,
- Shuwen Sun,
- Wei Li,
- Wei Li,
- Xudong Yao,
- Xudong Yao,
- Zhengyan Chang,
- Yang Yan,
- Yang Yan
Affiliations
- Jingcheng Zhang
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Jingcheng Zhang
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Wentao Zhang
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Wentao Zhang
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Yuchao Liu
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Yuchao Liu
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Man Pi
- Department of Pathology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Yufeng Jiang
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Yufeng Jiang
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Ailiyaer Ainiwaer
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Ailiyaer Ainiwaer
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Shiyu Mao
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Shiyu Mao
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Haotian Chen
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Haotian Chen
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Yuefei Ran
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Yuefei Ran
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Shuwen Sun
- Cancer Institute, Xuzhou Medical University, Xuzhou, China
- Shuwen Sun
- Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- Wei Li
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Wei Li
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Xudong Yao
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Xudong Yao
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- Zhengyan Chang
- Department of Pathology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Yang Yan
- Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
- Yang Yan
- Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China
- DOI
- https://doi.org/10.3389/fendo.2022.1054216
- Journal volume & issue
-
Vol. 13
Abstract
The piRNA (PIWI-interacting RNA) is P-Element induced wimpy testis (PIWI)-interacting RNA which is a small molecule, non-coding RNA with a length of 24-32nt. It was originally found in germ cells and is considered a regulator of germ cell function. It can interact with PIWI protein, a member of the Argonaute family, and play a role in the regulation of gene transcription and epigenetic silencing of transposable factors in the nucleus. More and more studies have shown that piRNAs are abnormally expressed in a variety of cancer tissues and patient fluids, and may become diagnostic tools, therapeutic targets, staging markers, and prognostic evaluation tools for cancer. This article reviews the recent research on piRNA and summarizes the structural characteristics, production mechanism, applications, and its role in urological tumors, to provide a reference value for piRNA to regulate urological tumors.
Keywords
