Nature Communications (Jun 2017)
Prevalence of sexual dimorphism in mammalian phenotypic traits
- Natasha A. Karp,
- Jeremy Mason,
- Arthur L. Beaudet,
- Yoav Benjamini,
- Lynette Bower,
- Robert E. Braun,
- Steve D.M. Brown,
- Elissa J. Chesler,
- Mary E. Dickinson,
- Ann M. Flenniken,
- Helmut Fuchs,
- Martin Hrabe de Angelis,
- Xiang Gao,
- Shiying Guo,
- Simon Greenaway,
- Ruth Heller,
- Yann Herault,
- Monica J. Justice,
- Natalja Kurbatova,
- Christopher J. Lelliott,
- K.C. Kent Lloyd,
- Ann-Marie Mallon,
- Judith E. Mank,
- Hiroshi Masuya,
- Colin McKerlie,
- Terrence F. Meehan,
- Richard F. Mott,
- Stephen A. Murray,
- Helen Parkinson,
- Ramiro Ramirez-Solis,
- Luis Santos,
- John R. Seavitt,
- Damian Smedley,
- Tania Sorg,
- Anneliese O. Speak,
- Karen P. Steel,
- Karen L. Svenson,
- International Mouse Phenotyping Consortium,
- Shigeharu Wakana,
- David West,
- Sara Wells,
- Henrik Westerberg,
- Shay Yaacoby,
- Jacqueline K. White
Affiliations
- Natasha A. Karp
- Mouse Informatics Group, The Wellcome Trust Sanger Institute
- Jeremy Mason
- European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus
- Arthur L. Beaudet
- Human and Molecular Genetics, Baylor College of Medicine
- Yoav Benjamini
- Department of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University
- Lynette Bower
- Mouse Biology Program, University of California
- Robert E. Braun
- The Jackson Laboratory
- Steve D.M. Brown
- MRC Harwell Institute, Harwell Campus
- Elissa J. Chesler
- The Jackson Laboratory
- Mary E. Dickinson
- Molecular Physiology and Biophysics, Baylor College of Medicine
- Ann M. Flenniken
- The Centre for Phenogenomics
- Helmut Fuchs
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Martin Hrabe de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Xiang Gao
- Model Animal Research Center, Nanjing University
- Shiying Guo
- Model Animal Research Center, Nanjing University
- Simon Greenaway
- MRC Harwell Institute, Harwell Campus
- Ruth Heller
- Department of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University
- Yann Herault
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris
- Monica J. Justice
- The Hospital for Sick Children
- Natalja Kurbatova
- Department of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University
- Christopher J. Lelliott
- Mouse Genetics Project, The Wellcome Trust Sanger Institute
- K.C. Kent Lloyd
- Mouse Biology Program, University of California
- Ann-Marie Mallon
- MRC Harwell Institute, Harwell Campus
- Judith E. Mank
- Department of Genetics, Evolution & Environment, University College London
- Hiroshi Masuya
- BioResource Center, RIKEN
- Colin McKerlie
- The Centre for Phenogenomics
- Terrence F. Meehan
- European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus
- Richard F. Mott
- Genetics Institute, University College London
- Stephen A. Murray
- The Jackson Laboratory
- Helen Parkinson
- European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus
- Ramiro Ramirez-Solis
- Mouse Genetics Project, The Wellcome Trust Sanger Institute
- Luis Santos
- MRC Harwell Institute, Harwell Campus
- John R. Seavitt
- Human and Molecular Genetics, Baylor College of Medicine
- Damian Smedley
- Clinical Pharmacology, Queen Mary University of London
- Tania Sorg
- CELPHEDIA, PHENOMIN, Institut Clinique de la Souris
- Anneliese O. Speak
- Mouse Genetics Project, The Wellcome Trust Sanger Institute
- Karen P. Steel
- Mouse Genetics Project, The Wellcome Trust Sanger Institute
- Karen L. Svenson
- The Jackson Laboratory
- International Mouse Phenotyping Consortium
- Shigeharu Wakana
- BioResource Center, RIKEN
- David West
- Children’s Hospital Oakland Research Institute
- Sara Wells
- MRC Harwell Institute, Harwell Campus
- Henrik Westerberg
- MRC Harwell Institute, Harwell Campus
- Shay Yaacoby
- Department of Statistics and O.R. School of Mathematical Sciences, Tel Aviv University
- Jacqueline K. White
- The Jackson Laboratory
- DOI
- https://doi.org/10.1038/ncomms15475
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.
