The within-host viral kinetics of SARS-CoV-2

Chentong Li; Jinhu Xu; Jiawei Liu; Yicang Zhou

doi:10.3934/mbe.2020159

Mathematical Biosciences and Engineering (Mar 2020)

The within-host viral kinetics of SARS-CoV-2

Chentong Li ,
Jinhu Xu,
Jiawei Liu ,
Yicang Zhou

Affiliations

Chentong Li: 1. School of Mathematics and Statistics, Xi’an Jiaotong University, Xi’an, 710049, China
Jinhu Xu: 2. School of Sciences, Xi’an University of Technology, Xi’an, 710048, China
Jiawei Liu: 3. Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
Yicang Zhou: 1. School of Mathematics and Statistics, Xi’an Jiaotong University, Xi’an, 710049, China

DOI: https://doi.org/10.3934/mbe.2020159
Journal volume & issue: Vol. 17, no. 4
pp. 2853 – 2861

Abstract

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In this work, we use a within-host viral dynamic model to describe the SARS-CoV-2 kinetics in the host. Chest radiograph score data are used to estimate the parameters of that model. Our result shows that the basic reproductive number of SARS-CoV-2 in host growth is around 3.79. Using the same method we also estimate the basic reproductive number of MERS virus is 8.16 which is higher than SARS-CoV-2. The PRCC method is used to analyze the sensitivities of model parameters. Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model.

Published in Mathematical Biosciences and Engineering

ISSN: 1551-0018 (Online)
Publisher: AIMS Press
Country of publisher: United States
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Mathematics
Website: https://www.aimspress.com/journal/MBE

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