Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model

Mark J. Bailey; James Duehr; Harrison Dulin; Felix Broecker; Julia A. Brown; Fortuna O. Arumemi; Maria C. Bermúdez González; Victor H. Leyva-Grado; Matthew J. Evans; Viviana Simon; Jean K. Lim; Florian Krammer; Rong Hai; Peter Palese; Gene S. Tan

doi:10.1038/s41467-018-07008-0

Nature Communications (Nov 2018)

Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model

Mark J. Bailey,
James Duehr,
Harrison Dulin,
Felix Broecker,
Julia A. Brown,
Fortuna O. Arumemi,
Maria C. Bermúdez González,
Victor H. Leyva-Grado,
Matthew J. Evans,
Viviana Simon,
Jean K. Lim,
Florian Krammer,
Rong Hai,
Peter Palese,
Gene S. Tan

Affiliations

Mark J. Bailey: Department of Microbiology, Icahn School of Medicine at Mount Sinai
James Duehr: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Harrison Dulin: Department of Plant Pathology and Microbiology, University of California Riverside
Felix Broecker: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Julia A. Brown: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Fortuna O. Arumemi: Infectious Diseases, The J. Craig Venter Institute
Maria C. Bermúdez González: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Victor H. Leyva-Grado: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Matthew J. Evans: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Viviana Simon: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Jean K. Lim: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Florian Krammer: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Rong Hai: Department of Plant Pathology and Microbiology, University of California Riverside
Peter Palese: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Gene S. Tan: Infectious Diseases, The J. Craig Venter Institute

DOI: https://doi.org/10.1038/s41467-018-07008-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Zika virus infection can cause severe disease in humans and there are currently no specific treatments or vaccines. Here, Bailey et al. isolate antibodies recognizing non-structural protein NS1 and show that they protect mice from disease by an Fc-dependent, non-neutralizing mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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