Frontiers in Immunology (Jul 2023)

Case Report: Immunotherapy for low-grade myofibroblastic sarcoma of the pharynx

  • Bao Sun,
  • Bao Sun,
  • Zhiying Luo,
  • Zhiying Luo,
  • Ping Liu,
  • Yan He,
  • Shasha He,
  • Wenhui Liu,
  • Wenhui Liu

DOI
https://doi.org/10.3389/fimmu.2023.1190210
Journal volume & issue
Vol. 14

Abstract

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Low-grade myofibroblastic sarcoma (LGMS) characterized by the increased proliferation of myofibroblasts is a rare type of malignant myofibroblastic tumor that frequently occurs in the head and neck region. Presently, there is no consensus regarding the treatment of LGMS. Here, we report a rare case of LGMS of the pharynx in a 40-year-old male admitted to our hospital. The patient underwent resection for a right metastatic lesion and parapharyngeal mass. However, he had recurrence and multiple metastases without a surgical indication. Then the patient received the treatment of anlotinib plus pembrolizumab for 4 cycles, and there was a partial response (PR) to the treatment. Due to the adverse reaction of anlotinib, the patient subsequently received monotherapy of pembrolizumab for 22 cycles and achieved a complete response (CR). As the first case report of the immunotherapy for LGMS, our study highlights that this strategy may be of great significance to the treatment of LGMS.

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