Association Between Habitual Night Sleep Duration and Predicted 10-Year Cardiovascular Risk by Sex Among Young and Middle-Aged Adults

Abstract

Jiangshan He,1 Yuxue Wang,1 Li Zhang,2 Chunjun Li,3 Xin Qi,3 Jianxiong Wang,4 Pei Guo,1 Shuo Chen,5 Yujie Niu,6,7 Feng Liu,5 Rong Zhang,6,7 Qiang Li,5 Shitao Ma,6,7 Mianzhi Zhang,8,9 Chenglin Hong,10 Minying Zhang1 1School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Tianjin First Central Hospital, Tianjin, People’s Republic of China; 3Tianjin Union Medical Center, Tianjin, People’s Republic of China; 4Graduate School of Tianjin Medical University, Tianjin, People’s Republic of China; 5Beijing Physical Examination Center, Beijing, People’s Republic of China; 6Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, People’s Republic of China; 7Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang, People’s Republic of China; 8Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 9Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, People’s Republic of China; 10Department of Social Welfare, School of Public Affairs, University of California, Los Angeles, CA, USACorrespondence: Minying Zhang, School of Medicine, Nankai University, 94 Weijin Road, Nankai District, Tianjin, 300071, People’s Republic of China, Tel [phone], Fax [phone], Email [email protected]: We hypothesize the association between sleep duration and cardiovascular disease (CVD) risk varies with age category; however, evidence for the relationship between sleep duration and CVD risk among young and middle-aged adults remains scarce. This research aims to assess the association between night sleep duration and cardiovascular risk by sex among young and middle-aged Chinese adults.Patients and Methods: We used the baseline data of a cohort of adults for physical examination by stratified cluster sampling. The Framingham risk score and the Pittsburgh Sleep Quality Index were used to measure CVD risk and sleep duration, respectively. Demographic characteristics, lifestyle factors, height, weight, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were collected. We performed multiple logistic regressions to examine the association between night sleep duration and the predicted cardiovascular risk.Results: We included 27,547 participants aged 18– 64 years free of CVD, cerebral stroke, and not taking lipid-lowering agents. Overall, 12.7%, and 20.4% were at medium and high predicted CVD risk, respectively; 11.9% and 12.3% reported short and long sleep, respectively. Short sleep was independently associated with 23% (95% CI: 1.08– 1.40) increased odds of medium-to-high CVD risk and 26% (95% CI: 1.11– 1.45) increased odds of high CVD risk among females. Whereas long sleep was independently associated with 17% (95% CI: 0.71– 0.98) decreased odds of medium-to-high CVD risk among males.Conclusion: Among young and middle-aged adults, long sleep was associated with decreased odds of CVD risk in males, whereas short sleep was associated with increased odds of cardiovascular risk in females.Keywords: predicted 10-year CVD risk, sleep duration, Framingham risk score, young and middle-aged population

Keywords

• predicted 10-year cvd risk
• sleep duration
• framingham risk score
• young and middle-aged population