Molecules
(Jun 2015)
Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition
Wen-Chang Chen,
Veerababurao Kavala,
Yu-Hsuan Shih,
Yu-Hsuan Wang,
Chun-Wei Kuo,
Tang-Hao Yang,
Chia-Yu Huang,
Hao-Hsiang Chiu,
Ching-Fa Yao
Affiliations
Wen-Chang Chen
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Veerababurao Kavala
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Yu-Hsuan Shih
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Yu-Hsuan Wang
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Chun-Wei Kuo
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Tang-Hao Yang
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Chia-Yu Huang
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Hao-Hsiang Chiu
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
Ching-Fa Yao
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
DOI
https://doi.org/10.3390/molecules200610910
Journal volume & issue
Vol. 20,
no. 6
Abstract
Read online
An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.
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