Neuropsychiatric Disease and Treatment (Apr 2021)
Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?
Abstract
Rebecca Perrain,1,2 David Calvet,3– 5 Vincent Guiraud,3– 5 Lila Mekaoui,1 Jean-Louis Mas,3– 5 Philip Gorwood1,2,5 1GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris, France; 2University of Paris, Paris, France; 3GHU Paris Psychiatrie et Neurosciences, Department of Neurology, Hôpital Sainte-Anne, Paris, France; 4University of Paris, FHU Neurovasc, Paris, France; 5Institute of Psychiatry and Neuroscience of Paris, INSERMU1266, Paris, FranceCorrespondence: Rebecca PerrainClinique des Maladies Mentales et de l’Encéphale, Sainte-Anne Hospital, GHU Paris– Psychiatrie & Neurosciences, 100 rue de la Santé 75674 Paris Cedex 14, Paris, FranceTel +33 1 45 65 83 64Fax +33 1 45 65 76 56Email [email protected]: Post-stroke depression (PSD) affects one third of stroke survivors, with multiple severe negative consequences. We aim to assess the weight of four different types of clinical risk factors for PSD.Patients and Methods: We conducted a prospective cohort study in a stroke centre. After stroke, patients were assessed for cognitive performances, psychiatric standardized questionnaires and socio-demographic features. They were called three months after and assessed for major depressive episode using DSM criteria.Results: PSD was diagnosed in 8 of the 59 (13.6%) patients enrolled in the study. After multivariate analysis, only “previous history of depressive episode” remained a significant predictive factor for PSD, the model explaining 19% of the total variance (OR=18.0; p=0.002). Patients with a previous history of depression had a 10-fold increased risk for PSD.Conclusion: Previous history of depression is confirmed as a strong risk factor for PDS and allow the identification of an at-risk sub-group of patients.Keywords: post-stroke depression, depression, stroke, risk factors, prevention, cohort
