IMPACT OF THE ANESTHETIC METHOD ON LIPID PEROXIDATION ACTIVITY DURING CAROTID ENDARTERECTOMY

Abstract

The objective of the study: to assess the effect of two types of general anesthesia on lipid peroxidation and to establish a correlation between the degree of its activation and the number of post-operative neurological disorders.Subjects and methods. 130 patients (84 men and 46 women) at the age from 48 to 68 years were examined, they all were admitted to hospital for carotid endarterectomy due to atherosclerosis of internal carotid artery. The blind envelopes method was used for randomization. The patients were divided into 2 groups. The control group included 20 practically healthy persons (the median age made 50 ± 2 years).Propofol was used for anesthesia in 60 patients (Group 1), while sevoflurane was used in 70 patients (Group 2). Student test was used for statistical processing of data. The critical significance level corresponded to p < 0.05. The groups were considered representative based on 12 attributes.During the surgery, the following parameters were monitored: oxidant and anti-oxidant statuses, markers of neuronal damage; post-operative neurological complications were assessed.Results. When comparing and assessing the rates of the general pro-oxidant activity and general anti-oxidant activity in the patients from both groups, the initial rates of oxidant and anti-oxidant statuses did not confidently differ, which can be explained by the homogeneity of the patients' examinations.The activation of general pro-oxidant activity and general anti-oxidant activity was higher in Group 1 at the moment of carotid clamping. The same tendency was observed during the restoration of cerebral blood flow.The intensity of lipid peroxidation activation correlated with the frequency of post-operative neurological disorders and it was lower in Group 2.

Keywords

• carotid endarterectomy
• lipid peroxidation
• markers of neuronal damage
• atherosclerosis
• carotid