Pre-activation of autophagy impacts response to olaparib in prostate cancer cells

Maxime Cahuzac; Patricia Langlois; Benjamin Péant; Hubert Fleury; Anne-Marie Mes-Masson; Fred Saad

doi:10.1038/s42003-022-03210-5

Communications Biology (Mar 2022)

Pre-activation of autophagy impacts response to olaparib in prostate cancer cells

Maxime Cahuzac,
Patricia Langlois,
Benjamin Péant,
Hubert Fleury,
Anne-Marie Mes-Masson,
Fred Saad

Affiliations

Maxime Cahuzac: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)
Patricia Langlois: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)
Benjamin Péant: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)
Hubert Fleury: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)
Anne-Marie Mes-Masson: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)
Fred Saad: Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM)

DOI: https://doi.org/10.1038/s42003-022-03210-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

Pre-activation of autophagy mediates resistance to olaparib by decreasing nuclear SQSTM1/p62, which increases homologous recombination-mediated repair through filamin A expression and BRCA1/Rad51 recruitment.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal