Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine

Wilfried Kugler; Leo Veenman; Yulia Shandalov; Svetlana Leschiner; Ilana Spanier; Max Lakomek; Moshe Gavish

doi:10.3233/CLO-2008-0431

Cellular Oncology (Jan 2008)

Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine

Wilfried Kugler,
Leo Veenman,
Yulia Shandalov,
Svetlana Leschiner,
Ilana Spanier,
Max Lakomek,
Moshe Gavish

Affiliations

Wilfried Kugler: Abteilung Pädiatrie I, Zentrum Kinderheilkunde und Jugendmedizin, Universitätsklinikum Göttingen, D-37075 Göttingen, Germany
Leo Veenman: Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, Israel
Yulia Shandalov: Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, Israel
Svetlana Leschiner: Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, Israel
Ilana Spanier: Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, Israel
Max Lakomek: Abteilung Pädiatrie I, Zentrum Kinderheilkunde und Jugendmedizin, Universitätsklinikum Göttingen, D-37075 Göttingen, Germany
Moshe Gavish: Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, Israel

DOI: https://doi.org/10.3233/CLO-2008-0431
Journal volume & issue: Vol. 30, no. 5
pp. 435 – 450

Abstract

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Background: We have previously shown that the anti-neoplastic agent erucylphosphohomocholine (ErPC3) requires the mitochondrial 18 kDa Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), to induce cell death via the mitochondrial apoptosis pathway.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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