Selection Criteria and Treatment Outcome for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Unfit for Platinum-Based First-Line Therapy: Results of the MOON-OSS Observational Trial

Andrea Camerini; Alessandro Del Conte; Aldo Pezzuto; Vieri Scotti; Francesco Facchinetti; Lucia Pia Ciccone; Marco Perna; Giulia Sartori; Cheti Puccetti; Alberto Ricci; Antonio Santo; Marcello Tiseo; Domenico Amoroso

doi:10.3390/cancers14246074

Cancers (Dec 2022)

Selection Criteria and Treatment Outcome for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Unfit for Platinum-Based First-Line Therapy: Results of the MOON-OSS Observational Trial

Andrea Camerini,
Alessandro Del Conte,
Aldo Pezzuto,
Vieri Scotti,
Francesco Facchinetti,
Lucia Pia Ciccone,
Marco Perna,
Giulia Sartori,
Cheti Puccetti,
Alberto Ricci,
Antonio Santo,
Marcello Tiseo,
Domenico Amoroso

Affiliations

Andrea Camerini: Medical Oncology, Versilia Hospital, Via Aurelia 335, 55043 Lido di Camaiore, LU, Italy
Alessandro Del Conte: S.O.C. Oncologia Medica e dei Tumori Immunocorrelati—CRO/IRCCS Aviano Via Gallini 2, 33081 Pordenone, PN, Italy
Aldo Pezzuto: Cardiovascular and Respiratory Sciences Department, Sant’Andrea Hospital, Via di Grottarossa 1035/1039, 00189 Roma, Italy
Vieri Scotti: Radiation Oncology Unit, Oncology Department, AOU Careggi, Largo Brambilla 3, 50134 Firenze, Italy
Francesco Facchinetti: Institut Gustave Roussy, Inserm, Biomarqueurs Prédictifs et Nouvelles Stratégies Thérapeutiques en Oncologie, Université Paris-Saclay, 114 Rue Vaillant, 94800 Villejuif, France
Lucia Pia Ciccone: Radiation Oncology Unit, Oncology Department, AOU Careggi, Largo Brambilla 3, 50134 Firenze, Italy
Marco Perna: Radiation Oncology Unit, Oncology Department, AOU Careggi, Largo Brambilla 3, 50134 Firenze, Italy
Giulia Sartori: Section of Medical Oncology, Department of Medicine, University of Verona, Piazzale Stefani 1, 37126 Verona, Italy
Cheti Puccetti: Medical Oncology, Versilia Hospital, Via Aurelia 335, 55043 Lido di Camaiore, LU, Italy
Alberto Ricci: Department of Clinical and Molecular Medicine, Università La Sapienza, Via di Grottarossa 1015, 00189 Roma, Italy
Antonio Santo: Lung Unit, Ospedale Pederzoli—Via Monte Baldo 24, 37019 Peschiera del Garda, VR, Italy
Marcello Tiseo: Medical Oncology Unit, University Hospital of Parma, Viale Gramsci 14, 43126 Parma, Italy
Domenico Amoroso: Medical Oncology, Versilia Hospital, Via Aurelia 335, 55043 Lido di Camaiore, LU, Italy

DOI: https://doi.org/10.3390/cancers14246074
Journal volume & issue: Vol. 14, no. 24
p. 6074

Abstract

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Limited evidence is available concerning the selection criteria and the outcomes of platinum unfit newly diagnosed advanced NSCLC patients receiving single-agent chemotherapy. We retrospectively collected data on consecutive, stage IIIB-IV, EGFR/ALK negative and PD-L1 70 years), comorbidities and poor PS. An oral treatment was frequently proposed with MetV being the most frequent choice according to its safety profile.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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