Effect of sodium nitroprusside on parameters of electrical and contractile activities of lower esophageal sphincter unstriped muscles

Abstract

Investigations of electrical and contractile activities of lower esophageal sphincter unstriped muscles under sodium nitroprusside impact have been fulfilled by the method of double sucrose gap. Effect of nitric oxide donor on potassium and calcium membrane conductance has been evaluated, as well as the role of intracellular NO-synthase. Membrane hyperpolarization and contractile activity decrease during the use of sodium nitroprusside and L-NAME have been observed. Conclusion has been drawn of NO effect on potassium membrane conductance as well as of the possible effect on contractile proteins and activation of cAMP-dependent regulation of LES UM physiological functions.

Keywords

• нижний пищеводный сфинктер
• нитропруссид натрия
• сократительная активность
• гладкая мышца