Evaluation of Biochemical Oxidative Stress Indices in Male Wistar Rats Treated with Swinol Tablets

Abstract

Drug consumption considerably contributes to organ damage and metabolic disorder, yet the precise biochemical effect of Swinol remain unknown. The objective of this paper was to evaluate the biochemical oxidative stress indices of male wistar rats treated with swinol tablet using appropriate standard methods. Results demonstrated a dose-dependent decline in antioxidant activity in the liver and kidney with increasing doses of swinol tablets, evidenced by decreased superoxide dismutase (SOD), catalase, glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST). This connotes an impaired antioxidant defense in rats treated with Swinol tablets. Additionally, lipid peroxidation readings dramatically increased, suggesting heightened oxidative damage, particularly with greater Swinol doses. These studies show that continued administration of Swinol tablets increases oxidative stress by lowering antioxidant capacity and promoting lipid peroxidation, which may lead to organ malfunction. Further investigation is necessary to explore the long-term health risks connected with Swinol misuse.

Keywords

• Oxidative stress; Swinol tablet; Organ dysfunction; Antioxidant biomarkers; lipid peroxidation