Nature Communications (Jan 2016)
A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice
- Haoxing Zhang,
- Hailong Liu,
- Yali Chen,
- Xu Yang,
- Panfei Wang,
- Tongzheng Liu,
- Min Deng,
- Bo Qin,
- Cristina Correia,
- Seungbaek Lee,
- Jungjin Kim,
- Melanie Sparks,
- Asha A. Nair,
- Debra L. Evans,
- Krishna R. Kalari,
- Pumin Zhang,
- Liewei Wang,
- Zhongsheng You,
- Scott H. Kaufmann,
- Zhenkun Lou,
- Huadong Pei
Affiliations
- Haoxing Zhang
- School of Life Sciences, Southwest University
- Hailong Liu
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Yali Chen
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Xu Yang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Panfei Wang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Tongzheng Liu
- Division of Oncology Research, Mayo Clinic, Rochester
- Min Deng
- Division of Oncology Research, Mayo Clinic, Rochester
- Bo Qin
- Division of Oncology Research, Mayo Clinic, Rochester
- Cristina Correia
- Division of Oncology Research, Mayo Clinic, Rochester
- Seungbaek Lee
- Division of Oncology Research, Mayo Clinic, Rochester
- Jungjin Kim
- Division of Oncology Research, Mayo Clinic, Rochester
- Melanie Sparks
- Department of Cell Biology and Physiology, Washington University
- Asha A. Nair
- BSI-Genetics & Bioinformatics, Mayo Clinic
- Debra L. Evans
- Division of Oncology Research, Mayo Clinic, Rochester
- Krishna R. Kalari
- BSI-Genetics & Bioinformatics, Mayo Clinic
- Pumin Zhang
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Liewei Wang
- Molecular Pharmacology and Experimental therapeutics, Mayo Clinic
- Zhongsheng You
- Department of Cell Biology and Physiology, Washington University
- Scott H. Kaufmann
- Division of Oncology Research, Mayo Clinic, Rochester
- Zhenkun Lou
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Huadong Pei
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- DOI
- https://doi.org/10.1038/ncomms10201
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
BRCA1 is a key regulator of DNA double-strand break repair, functioning to promote homologous recombination and repress non-homologous end-joining. Here the authors show that the ubiquitin ligase UHRF1 is recruited to breaks by BRCA1, where it targets RIF1 and thereby facilitates recombination.
