mBio
(Oct 2021)
The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway
Ling Wang,
Mary E. A. Howell,
Ayrianna Sparks-Wallace,
Juan Zhao,
Culton R. Hensley,
Camri A. Nicksic,
Shanna R. Horne,
Kaylea B. Mohr,
Jonathan P. Moorman,
Zhi Q. Yao,
Shunbin Ning
Affiliations
Ling Wang
ORCiD Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Mary E. A. Howell
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Ayrianna Sparks-Wallace
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Juan Zhao
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Culton R. Hensley
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Camri A. Nicksic
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Shanna R. Horne
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Kaylea B. Mohr
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Jonathan P. Moorman
Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Zhi Q. Yao
ORCiD Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Shunbin Ning
ORCiD Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
DOI
https://doi.org/10.1128/mBio.01097-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.
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