The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

Ling Wang; Mary E. A. Howell; Ayrianna Sparks-Wallace; Juan Zhao; Culton R. Hensley; Camri A. Nicksic; Shanna R. Horne; Kaylea B. Mohr; Jonathan P. Moorman; Zhi Q. Yao; Shunbin Ning

doi:10.1128/mBio.01097-21

mBio (Oct 2021)

The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

Ling Wang,
Mary E. A. Howell,
Ayrianna Sparks-Wallace,
Juan Zhao,
Culton R. Hensley,
Camri A. Nicksic,
Shanna R. Horne,
Kaylea B. Mohr,
Jonathan P. Moorman,
Zhi Q. Yao,
Shunbin Ning

Affiliations

Ling Wang: ORCiD; Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Mary E. A. Howell: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Ayrianna Sparks-Wallace: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Juan Zhao: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Culton R. Hensley: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Camri A. Nicksic: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Shanna R. Horne: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Kaylea B. Mohr: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Jonathan P. Moorman: Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Zhi Q. Yao: ORCiD; Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA
Shunbin Ning: ORCiD; Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

DOI: https://doi.org/10.1128/mBio.01097-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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As a ubiquitin sensor and a signal-transducing adaptor, p62 is crucial for NF-κB activation, which involves the ubiquitin machinery in diverse contexts. However, whether p62 is required for EBV LMP1 activation of NF-κB is an open question.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal