Proceedings
(Mar 2024)
Noncoding Regulatory Mutations as a Driving Event for the Oncogenic Core Regulatory Circuitries of Neuroblastoma
Vincenzo Aievola,
Vito Alessandro Lasorsa,
Annalaura Montella,
Ferdinando Bonfiglio,
Marianna Avitabile,
Teresa Maiorino,
Matilde Tirelli,
Giuseppe D’Alterio,
Matthias Fischer,
Frank Westermann,
Achille Iolascon,
Mario Capasso
Affiliations
Vincenzo Aievola
Department of Electrical Engineering and Information Technologies, University of Naples Federico II, Naples 80125, Italy
Vito Alessandro Lasorsa
CEINGE Biotecnologie Avanzate Franco Salvatore s.c.ar.l., Naples 80131, Italy
Annalaura Montella
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Ferdinando Bonfiglio
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Marianna Avitabile
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Teresa Maiorino
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Matilde Tirelli
European School of Molecular Medicine, University of Milan, Milan 20139, Italy
Giuseppe D’Alterio
European School of Molecular Medicine, University of Milan, Milan 20139, Italy
Matthias Fischer
Experimental Pediatric Oncology, Children’s Hospital and Center for Molecular Medicine, Medical Faculty, University of Cologne, Cologne 50937, Germany
Frank Westermann
Hopp-Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg 69120, Germany
Achille Iolascon
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Mario Capasso
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
DOI
https://doi.org/10.3390/proceedings2024100018
Journal volume & issue
Vol. 100,
no. 1
p.
18
Abstract
Read online
Neuroblastoma (NB) is a pediatric tumor composed of adrenergic (ADRN) and mesenchymal-like (MES) cells which derive from the dysregulation of normal cell differentiation imposed by NB Core Regulatory Circuitries (CRCs) [...]
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