PLoS ONE (Jan 2023)

Impact of acute TTE-evidenced cardiac dysfunction on in-hospital and outpatient mortality: A multicenter NYC COVID-19 registry study.

  • Edwin A Homan,
  • Richard B Devereux,
  • Katherine A Tak,
  • Hannah W Mitlak,
  • Alexander Volodarskiy,
  • Kumudha Ramasubbu,
  • David T Zhang,
  • Arielle Kushman,
  • Meridith P Pollie,
  • Hannah K Agoglia,
  • Romina Tafreshi,
  • Parag Goyal,
  • Leslee Shaw,
  • Lishomwa Ndhlovu,
  • Arindam RoyChoudhury,
  • Evelyn Horn,
  • Nupoor Narula,
  • Monika M Safford,
  • Jonathan W Weinsaft,
  • Jiwon Kim

DOI
https://doi.org/10.1371/journal.pone.0283708
Journal volume & issue
Vol. 18, no. 3
p. e0283708

Abstract

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BackgroundCOVID-19 is associated with cardiac dysfunction. This study tested the relative prognostic role of left (LV), right and bi- (BiV) ventricular dysfunction on mortality in a large multicenter cohort of patients during and after acute COVID-19 hospitalization.Methods/resultsAll hospitalized COVID-19 patients who underwent clinically indicated transthoracic echocardiography within 30 days of admission at four NYC hospitals between March 2020 and January 2021 were studied. Images were re-analyzed by a central core lab blinded to clinical data. Nine hundred patients were studied (28% Hispanic, 16% African-American), and LV, RV and BiV dysfunction were observed in 50%, 38% and 17%, respectively. Within the overall cohort, 194 patients had TTEs prior to COVID-19 diagnosis, among whom LV, RV, BiV dysfunction prevalence increased following acute infection (pConclusionsLV, RV and BiV function declines during acute COVID-19 infection with each contributing to increased in- and out-patient mortality risk. RV dysfunction independently increases mortality risk.