Nature Communications (Feb 2022)
Development of a skin- and neuro-attenuated live vaccine for varicella
- Wei Wang,
- Dequan Pan,
- Wenkun Fu,
- Xiangzhong Ye,
- Jinle Han,
- Lianwei Yang,
- Jizong Jia,
- Jian Liu,
- Rui Zhu,
- Yali Zhang,
- Che Liu,
- Jianghui Ye,
- Anca Selariu,
- Yuqiong Que,
- Qinjian Zhao,
- Ting Wu,
- Yimin Li,
- Jun Zhang,
- Tong Cheng,
- Hua Zhu,
- Ningshao Xia
Affiliations
- Wei Wang
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Dequan Pan
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Wenkun Fu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Xiangzhong Ye
- Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.
- Jinle Han
- Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.
- Lianwei Yang
- Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.
- Jizong Jia
- Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.
- Jian Liu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Rui Zhu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Yali Zhang
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Che Liu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Jianghui Ye
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Anca Selariu
- Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University
- Yuqiong Que
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Qinjian Zhao
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Ting Wu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Yimin Li
- Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.
- Jun Zhang
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Tong Cheng
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- Hua Zhu
- Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University
- Ningshao Xia
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-022-28329-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Current varicella vaccines retain neurovirulence and can establish latency and reactivate. Here, the authors present preclinical results of a rationally-designed, skin- and neuro-attenuated varicella vaccine candidate, v7D, showing its attenuation in human skin and neuronal cells and its immunogenicity in small animal models and nonhuman primates
