Fecal microbiota transplantation as a treatment option for patients with recurrent Clostridioides difficile-associated diarrhea

Abstract

This paper provides a review of the largest studies (over the period of 2017 to 2022) on the use of fecal microbiota transplantation (FMT) for the treatment of patients with recurrent Clostridioides difficileassociated diarrhea (CDAD), including pseudomembranous colitis. A focus was made on methods of preparation and administration of fecal microbiota product. The recent systematic reviews and metaanalyses consistently consider TFM as an effective treatment option for recurrent CDAD. The different methods of fecal microbiota preparation and administration (fresh, frozen, lyophilized) show similar efficacy but differ by convenience of use.

Keywords

• clostridioides difficile
• antibiotic-associated diarrhea
• pseudomembranous colitis
• treatment
• fecal microbiota transplantation