Silica gel-based electrochemical sensor for tinidazole

Abstract

A sensitive method has been proposed for electrochemical reduction of tinidazole (TNZ) drugs employing a voltammetric approach. The supporting electrolyte, phosphate buffer solution (PBS) was prepared for different pH levels (3.0–8.0). The method involves a silica gel modified carbon paste electrode (SG/CPE) as an electrochemical sensor which demonstrated exceptional selectivity and sensitivity towards the detection of TNZ. Various parameters like the impact of accumulation time, pH of supporting buffer, scan rate, and concentration on electro-analysis of TNZ were examined. By the pH study, it was evident that the same number of protons and electrons participated in the process and by scan rate studies, we have estimated the heterogeneous rate constant and electron number. The process was irreversible and diffusion controlled. The linearity range was found to be 1.0 ​μM–10.0 ​μM from concentration variation studies. The detection and quantification limit was calculated and the practical applicability of a developed sensor is tested for tablet and urine samples. The reports obtained by studying the different parameters revealed that the electrode has good stability and sensitivity with reproducible results.

Keywords

• Electroanalysis
• Voltammetry
• Electrochemical sensor
• Tinidazole
• Silica gel