Nature Communications (Sep 2021)
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
- Ali Khateb,
- Anagha Deshpande,
- Yongmei Feng,
- Darren Finlay,
- Joo Sang Lee,
- Ikrame Lazar,
- Bertrand Fabre,
- Yan Li,
- Yu Fujita,
- Tongwu Zhang,
- Jun Yin,
- Ian Pass,
- Ido Livneh,
- Irmela Jeremias,
- Carol Burian,
- James R. Mason,
- Ronit Almog,
- Nurit Horesh,
- Yishai Ofran,
- Kevin Brown,
- Kristiina Vuori,
- Michael Jackson,
- Eytan Ruppin,
- Aniruddha J. Deshpande,
- Ze’ev A. Ronai
Affiliations
- Ali Khateb
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Anagha Deshpande
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Yongmei Feng
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Darren Finlay
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Joo Sang Lee
- Cancer Data Science Lab (CDSL), National Cancer Institute, National Institute of Health
- Ikrame Lazar
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Bertrand Fabre
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Yan Li
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Yu Fujita
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Tongwu Zhang
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jun Yin
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Ian Pass
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Ido Livneh
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Irmela Jeremias
- Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health
- Carol Burian
- Scripps MD Anderson Cancer Center
- James R. Mason
- Scripps MD Anderson Cancer Center
- Ronit Almog
- Rambam Health Care Campus, Epidemiology Department and Biobank
- Nurit Horesh
- Rambam Health Care Campus, Hematology and Bone marrow Transplantation Department
- Yishai Ofran
- Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology
- Kevin Brown
- Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kristiina Vuori
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Michael Jackson
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Eytan Ruppin
- Cancer Data Science Lab (CDSL), National Cancer Institute, National Institute of Health
- Aniruddha J. Deshpande
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Ze’ev A. Ronai
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- DOI
- https://doi.org/10.1038/s41467-021-25664-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which determines AML sensitivity to HDAC inhibitors.
