Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges
Mohamed Hemdan,
Mohamed A. Ali,
Ahmed S. Doghish,
Sherif S. Abdel Mageed,
Ibrahim M. Elazab,
Magdy M. Khalil,
Mostafa Mabrouk,
Diganta B. Das,
Alaa S. Amin
Affiliations
Mohamed Hemdan
School of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt
Mohamed A. Ali
School of Biotechnology, Badr University in Cairo (BUC), Badr City 11829, Egypt
Ahmed S. Doghish
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt
Sherif S. Abdel Mageed
Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt
Ibrahim M. Elazab
Department of Biochemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt
Magdy M. Khalil
Medical Biophysics, Department of Physics, Faculty of Science, Helwan University, Cairo 11795, Egypt
Mostafa Mabrouk
Refractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St., Giza 12622, Egypt
Diganta B. Das
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK
Alaa S. Amin
Chemistry Department, Faculty of Science, Benha University, Benha 13511, Egypt
This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection and therapeutic drug monitoring. It provides an in-depth analysis of various biosensor types and applications, including enzymatic sensors, immunosensors, and DNA sensors, elucidating their mechanisms and specific healthcare applications. The review highlights recent innovations such as integrating nanotechnology, developing wearable devices, and trends in miniaturisation, showcasing their transformative potential in healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, and data security challenges, proposing strategic solutions to overcome these obstacles. It is envisaged that it will inform strategic decision-making, drive technological innovation, and enhance global healthcare outcomes by synthesising multidisciplinary insights.
