Nature Communications (Jun 2016)
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
- Yujun Hao,
- Yardena Samuels,
- Qingling Li,
- Dawid Krokowski,
- Bo-Jhih Guan,
- Chao Wang,
- Zhicheng Jin,
- Bohan Dong,
- Bo Cao,
- Xiujing Feng,
- Min Xiang,
- Claire Xu,
- Stephen Fink,
- Neal J. Meropol,
- Yan Xu,
- Ronald A. Conlon,
- Sanford Markowitz,
- Kenneth W. Kinzler,
- Victor E. Velculescu,
- Henri Brunengraber,
- Joseph E. Willis,
- Thomas LaFramboise,
- Maria Hatzoglou,
- Guo-Fang Zhang,
- Bert Vogelstein,
- Zhenghe Wang
Affiliations
- Yujun Hao
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Yardena Samuels
- Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Qingling Li
- Department of Nutrition, Case Western Reserve University
- Dawid Krokowski
- Department of Pharmacology, School of Medicine, Case Western Reserve University
- Bo-Jhih Guan
- Department of Pharmacology, School of Medicine, Case Western Reserve University
- Chao Wang
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Zhicheng Jin
- Department of Nutrition, Case Western Reserve University
- Bohan Dong
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Bo Cao
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Xiujing Feng
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Min Xiang
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Claire Xu
- Hathaway Brown School
- Stephen Fink
- Case Comprehensive Cancer Center, Case Western Reserve University
- Neal J. Meropol
- Case Comprehensive Cancer Center, Case Western Reserve University
- Yan Xu
- Department of Chemistry, Cleveland State University
- Ronald A. Conlon
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Sanford Markowitz
- Case Comprehensive Cancer Center, Case Western Reserve University
- Kenneth W. Kinzler
- Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Victor E. Velculescu
- Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Henri Brunengraber
- Department of Nutrition, Case Western Reserve University
- Joseph E. Willis
- Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University
- Thomas LaFramboise
- Department of Genetics and Genome Sciences, Case Western Reserve University
- Maria Hatzoglou
- Department of Pharmacology, School of Medicine, Case Western Reserve University
- Guo-Fang Zhang
- Department of Nutrition, Case Western Reserve University
- Bert Vogelstein
- Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Zhenghe Wang
- Department of Genetics and Genome Sciences, Case Western Reserve University
- DOI
- https://doi.org/10.1038/ncomms11971
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.
