Communications Biology (Mar 2021)
Genomic insights into the host specific adaptation of the Pneumocystis genus
- Ousmane H. Cissé,
- Liang Ma,
- John P. Dekker,
- Pavel P. Khil,
- Jung-Ho Youn,
- Jason M. Brenchley,
- Robert Blair,
- Bapi Pahar,
- Magali Chabé,
- Koen K. A. Van Rompay,
- Rebekah Keesler,
- Antti Sukura,
- Vanessa Hirsch,
- Geetha Kutty,
- Yueqin Liu,
- Li Peng,
- Jie Chen,
- Jun Song,
- Christiane Weissenbacher-Lang,
- Jie Xu,
- Nathan S. Upham,
- Jason E. Stajich,
- Christina A. Cuomo,
- Melanie T. Cushion,
- Joseph A. Kovacs
Affiliations
- Ousmane H. Cissé
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH)
- Liang Ma
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH)
- John P. Dekker
- Bacterial Pathogenesis and Antimicrobial Resistance Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH
- Pavel P. Khil
- Bacterial Pathogenesis and Antimicrobial Resistance Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH
- Jung-Ho Youn
- Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health
- Jason M. Brenchley
- Laboratory of Viral Diseases, NIAID, NIH
- Robert Blair
- Tulane National Primate Research Center, Tulane University
- Bapi Pahar
- Tulane National Primate Research Center, Tulane University
- Magali Chabé
- Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Centre d’Infection et d’Immunité de Lille
- Koen K. A. Van Rompay
- California National Primate Research Center, University of California
- Rebekah Keesler
- California National Primate Research Center, University of California
- Antti Sukura
- Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Helsinki
- Vanessa Hirsch
- Laboratory of Molecular Microbiology, NIAID, NIH
- Geetha Kutty
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH)
- Yueqin Liu
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH)
- Li Peng
- Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University
- Jie Chen
- Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University
- Jun Song
- Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School
- Christiane Weissenbacher-Lang
- Institute of Pathology, Department of Pathobiology, University of Veterinary Medicine Vienna
- Jie Xu
- Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, University of Michigan Medical School
- Nathan S. Upham
- Arizona State University, School of Life Sciences
- Jason E. Stajich
- Department of Microbiology and Plant Pathology and Institute for Integrative Genome Biology, University of California, Riverside, Riverside-California
- Christina A. Cuomo
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Melanie T. Cushion
- Department of Internal Medicine, College of Medicine, University of Cincinnati
- Joseph A. Kovacs
- Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH)
- DOI
- https://doi.org/10.1038/s42003-021-01799-7
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Cissé, Ma et al. utilize genomic data from Pneumocystis species infecting macaques, rabbit, dogs and rats to investigate the molecular basis of host specificity in Pneumocystis. Their analyses provide insight to the specific adaptations enabling the infection of humans by P. jirovecii.
