Nature Communications (Aug 2021)
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
Abstract
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.