Nature Communications (Aug 2021)

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

  • Edd Ricker,
  • Michela Manni,
  • Danny Flores-Castro,
  • Daniel Jenkins,
  • Sanjay Gupta,
  • Juan Rivera-Correa,
  • Wenzhao Meng,
  • Aaron M. Rosenfeld,
  • Tania Pannellini,
  • Mahesh Bachu,
  • Yurii Chinenov,
  • Peter K. Sculco,
  • Rolf Jessberger,
  • Eline T. Luning Prak,
  • Alessandra B. Pernis

DOI
https://doi.org/10.1038/s41467-021-25102-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 21

Abstract

Read online

Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.