mBio
(Feb 2021)
Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop
Logan Banadyga,
Wenjun Zhu,
Shweta Kailasan,
Katie A. Howell,
Krzysztof Franaszek,
Shihua He,
Vinayakumar Siragam,
Keding Cheng,
Feihu Yan,
Estella Moffat,
Wenguang Cao,
Anders Leung,
Carissa Embury-Hyatt,
M. Javad Aman,
Xiangguo Qiu
Affiliations
Logan Banadyga
ORCiD Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Wenjun Zhu
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Shweta Kailasan
Integrated BioTherapeutics, Inc., Rockville, Maryland, USA
Katie A. Howell
Integrated BioTherapeutics, Inc., Rockville, Maryland, USA
Krzysztof Franaszek
Integrated BioTherapeutics, Inc., Rockville, Maryland, USA
Shihua He
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Vinayakumar Siragam
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Keding Cheng
Science and Technology Core, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Feihu Yan
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Estella Moffat
Canadian Food Inspection Agency, National Centre for Foreign and Animal Disease, Winnipeg, Canada
Wenguang Cao
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Anders Leung
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Carissa Embury-Hyatt
Canadian Food Inspection Agency, National Centre for Foreign and Animal Disease, Winnipeg, Canada
M. Javad Aman
Integrated BioTherapeutics, Inc., Rockville, Maryland, USA
Xiangguo Qiu
Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
DOI
https://doi.org/10.1128/mBio.01438-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Ebola virus remains a global threat to public health and biosecurity, yet we still know relatively little about its pathogenesis and the complications that arise following recovery. With nearly 20,000 survivors from the 2013–2016 West African outbreak, as well as over 1,000 survivors of the recent outbreak in the DRC, we must consider the consequences of virus persistence and recrudescent disease, even if they are rare.
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