Nature Communications (Aug 2017)
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors
- Allah Nawaz,
- Aminuddin Aminuddin,
- Tomonobu Kado,
- Akiko Takikawa,
- Seiji Yamamoto,
- Koichi Tsuneyama,
- Yoshiko Igarashi,
- Masashi Ikutani,
- Yasuhiro Nishida,
- Yoshinori Nagai,
- Kiyoshi Takatsu,
- Johji Imura,
- Masakiyo Sasahara,
- Yukiko Okazaki,
- Kohjiro Ueki,
- Tadashi Okamura,
- Kumpei Tokuyama,
- Akira Ando,
- Michihiro Matsumoto,
- Hisashi Mori,
- Takashi Nakagawa,
- Norihiko Kobayashi,
- Kumiko Saeki,
- Isao Usui,
- Shiho Fujisaka,
- Kazuyuki Tobe
Affiliations
- Allah Nawaz
- First Department of Internal Medicine, University of Toyama
- Aminuddin Aminuddin
- First Department of Internal Medicine, University of Toyama
- Tomonobu Kado
- First Department of Internal Medicine, University of Toyama
- Akiko Takikawa
- First Department of Internal Medicine, University of Toyama
- Seiji Yamamoto
- Department of Pathology, University of Toyama
- Koichi Tsuneyama
- Department of Diagnostic Pathology, University of Toyama
- Yoshiko Igarashi
- Division of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
- Masashi Ikutani
- Department of Immune Regulation, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine
- Yasuhiro Nishida
- First Department of Internal Medicine, University of Toyama
- Yoshinori Nagai
- Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
- Kiyoshi Takatsu
- Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
- Johji Imura
- Department of Diagnostic Pathology, University of Toyama
- Masakiyo Sasahara
- Department of Pathology, University of Toyama
- Yukiko Okazaki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Kohjiro Ueki
- Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
- Tadashi Okamura
- Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine
- Kumpei Tokuyama
- Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
- Akira Ando
- Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
- Michihiro Matsumoto
- Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
- Hisashi Mori
- Department of Molecular Neuroscience, University of Toyama
- Takashi Nakagawa
- Department of Metabolism and Nutrition, University of Toyama
- Norihiko Kobayashi
- Department of Disease Control, Research Institute, National Center for Global Health and Medicine
- Kumiko Saeki
- Department of Disease Control, Research Institute, National Center for Global Health and Medicine
- Isao Usui
- First Department of Internal Medicine, University of Toyama
- Shiho Fujisaka
- First Department of Internal Medicine, University of Toyama
- Kazuyuki Tobe
- First Department of Internal Medicine, University of Toyama
- DOI
- https://doi.org/10.1038/s41467-017-00231-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Adipose tissue contains macrophages that can influence both local and systemic metabolism via the secretion of cytokines. Here, Nawaz et al. report that M2-like macrophages, present in adipose tissue, create a microenvironment that inhibits proliferation of adipocyte progenitors due to the secretion of TGF-β1
