Communications Biology (Feb 2022)
Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance
- Sabine Ottilie,
- Madeline R. Luth,
- Erich Hellemann,
- Gregory M. Goldgof,
- Eddy Vigil,
- Prianka Kumar,
- Andrea L. Cheung,
- Miranda Song,
- Karla P. Godinez-Macias,
- Krypton Carolino,
- Jennifer Yang,
- Gisel Lopez,
- Matthew Abraham,
- Maureen Tarsio,
- Emmanuelle LeBlanc,
- Luke Whitesell,
- Jake Schenken,
- Felicia Gunawan,
- Reysha Patel,
- Joshua Smith,
- Melissa S. Love,
- Roy M. Williams,
- Case W. McNamara,
- William H. Gerwick,
- Trey Ideker,
- Yo Suzuki,
- Dyann F. Wirth,
- Amanda K. Lukens,
- Patricia M. Kane,
- Leah E. Cowen,
- Jacob D. Durrant,
- Elizabeth A. Winzeler
Affiliations
- Sabine Ottilie
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Madeline R. Luth
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Erich Hellemann
- Department of Biological Sciences, University of Pittsburgh
- Gregory M. Goldgof
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Eddy Vigil
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Prianka Kumar
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Andrea L. Cheung
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Miranda Song
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Karla P. Godinez-Macias
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Krypton Carolino
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Jennifer Yang
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Gisel Lopez
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Matthew Abraham
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Maureen Tarsio
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse
- Emmanuelle LeBlanc
- Department of Molecular Genetics, University of Toronto
- Luke Whitesell
- Department of Molecular Genetics, University of Toronto
- Jake Schenken
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Felicia Gunawan
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Reysha Patel
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Joshua Smith
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Melissa S. Love
- Calibr, a division of The Scripps Research Institutes
- Roy M. Williams
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- Case W. McNamara
- Calibr, a division of The Scripps Research Institutes
- William H. Gerwick
- Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography
- Trey Ideker
- Department of Medicine, University of California San Diego
- Yo Suzuki
- Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute
- Dyann F. Wirth
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Amanda K. Lukens
- Infectious Disease and Microbiome Program, Broad Institute
- Patricia M. Kane
- Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse
- Leah E. Cowen
- Department of Molecular Genetics, University of Toronto
- Jacob D. Durrant
- Department of Biological Sciences, University of Pittsburgh
- Elizabeth A. Winzeler
- Department of Pediatrics, University of California, San Diego, Gilman Dr
- DOI
- https://doi.org/10.1038/s42003-022-03076-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting their importance in drug resistance.
