Nature Communications (Apr 2022)

Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

  • Fernando Anjos-Afonso,
  • Florian Buettner,
  • Syed A. Mian,
  • Hefin Rhys,
  • Jimena Perez-Lloret,
  • Manuel Garcia-Albornoz,
  • Namrata Rastogi,
  • Linda Ariza-McNaughton,
  • Dominique Bonnet

DOI
https://doi.org/10.1038/s41467-022-29675-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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The trajectories of hematopoietic stem cells (HSCs) during lineage commitment are complex. Here, the authors use single cell RNA-sequencing and xenotransplantation to uncover CD34 + EPCR + (CD38/CD45RA)- HSCs, which high repopulating and self-renewal properties.