СРАВНИТЕЛЬНЫЙ АНАЛИЗ МАРКЁРОВ СИСТЕМНОГО ВОСПАЛИТЕЛЬНОГО ПРОЦЕССА У ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЁГКИХ В СОЧЕТАНИИ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА

Abstract

The study involved 112 patients with chronic obstructive pulmonary disease (COPD) of varying severity, and 13 patients with coronary heart disease (CHD). Patients with COPD and comorbidity CHD revealed increased activity of systemic inflammation in the form of increased serum levels of leukocytes, fibrinogen, CRP, TNF-α, IL-8, IFN-γ, as compared with isolated COPD. High activity of cytokines TNF-α, IL-8 correlates with the severity of bronchial obstruction, myocardial dysfunction, severity of comorbidity. The correlation between high activity TNF-α, IFN-γ with dyslipidemia and atherosclerosis.

Keywords

• chronic obstructive pulmonary disease
• coronary heart disease
• systemic inflammation
• il-8
• tnf-α
• inf-γ