Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness

Naoto Uda; Sawako Ogata; Norimasa Yamasaki; Shuka Miura; Naohisa Hosomi; Akio Mori; Minoru Gotoh; Kento Miura; Osamu Kaminuma

Journal of Pharmacological Sciences (Dec 2022)

Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness

Naoto Uda,
Sawako Ogata,
Norimasa Yamasaki,
Shuka Miura,
Naohisa Hosomi,
Akio Mori,
Minoru Gotoh,
Kento Miura,
Osamu Kaminuma

Affiliations

Naoto Uda: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan
Sawako Ogata: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan
Norimasa Yamasaki: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan
Shuka Miura: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan
Naohisa Hosomi: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan
Akio Mori: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, 18–1 Sakuradai, Minami-ku, Sagamihara 252–0392, Japan
Minoru Gotoh: Department of Otorhinolaryngology, Nippon Medical School, 1–1–5 Sendagi, Bunkyo-ku, Tokyo 113–8603, Japan
Kento Miura: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan
Osamu Kaminuma: Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1–2–3 Kasumi, Hiroshima, 734–8553, Japan; Corresponding author. Department of Disease Model, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Hiroshima, 734-8553, Japan.

Journal volume & issue: Vol. 150, no. 4
pp. 275 – 278

Abstract

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T cells play an essential role in the development of allergen-induced nasal hyperresponsiveness (NHR), a pathophysiological response in allergic rhinitis. The effects of histamine H1-receptor antagonists (antihistamines) on murine NHR models were investigated. Intragastric epinastine, fexofenadine, and loratadine administration suppressed allergen-induced immediate nasal response but not NHR in immunized mice. Regardless of the alleviation of stimulation-induced Th2 cytokine expression by loratadine and desloratadine in vitro, allergen-induced NHR and nasal eosinophil infiltration in Th2 cell–transferred mice were unaffected by loratadine in vivo. This influence on T cell–mediated NHR was excluded from the pharmacological effects of antihistamines.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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