Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation
Nicola Manfrini,
Sara Ricciardi,
Annarita Miluzio,
Maya Fedeli,
Alessandra Scagliola,
Simone Gallo,
Thure Adler,
Dirk H. Busch,
Valerie Gailus-Durner,
Helmut Fuchs,
Martin Hrabě de Angelis,
Stefano Biffo
Affiliations
Nicola Manfrini
National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, Italy
Sara Ricciardi
National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, Italy
Annarita Miluzio
National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, Italy
Maya Fedeli
Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, DIBIT, H. San Raffaele Scientific Institute, via Olgettina 58, 20132 Milan, Italy
Alessandra Scagliola
National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, Italy
Simone Gallo
National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, Italy
Thure Adler
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Dirk H. Busch
Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Trogerstrasse 30, 81675 Munich, Germany
Valerie Gailus-Durner
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Helmut Fuchs
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Martin Hrabě de Angelis
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Stefano Biffo
National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” - INGM, via F. Sforza 35, 20122 Milan, Italy
The data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans” (Manfrini et al., in press) [1]. eIF6 is a translation initiation factor required for ribosomal biogenesis (Sanvito et al., 1999) [2] and for proper translational initiation (Gallo and Manfrini, 2015; Miluzio et al., 2016) [3,4] whose protein abundance requires tight regulation. Here we analyze by flow cytometry the effects of eIF6 depletion on proportions of specific innate and adaptive immune system subpopulations and on thymocyte maturation in mice.
