Chemical Evaluation, Phytotoxic Potential, and In Silico Study of Essential Oils from Leaves of <i>Guatteria schomburgkiana</i> Mart. and <i>Xylopia frutescens</i> Aubl. (Annonaceae) from the Brazilian Amazon
Ângelo Antônio Barbosa de Moraes,
Márcia Moraes Cascaes,
Lidiane Diniz do Nascimento,
Celeste de Jesus Pereira Franco,
Oberdan Oliveira Ferreira,
Tainá Oliveira dos Anjos,
Himani Karakoti,
Ravendra Kumar,
Antônio Pedro da Silva Souza-Filho,
Mozaniel Santana de Oliveira,
Eloisa Helena de Aguiar Andrade
Affiliations
Ângelo Antônio Barbosa de Moraes
Faculdade de Engenharia Química, Instituto de Tecnologia, Universidade Federal do Pará, Rua Augusto Corrêa, 01, Guamá, Belem 66075-900, PA, Brazil
Márcia Moraes Cascaes
Laboratório Adolpho Ducke, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Av. Perimetral, 1901, Terra Firme, Belem 66077-830, PA, Brazil
Lidiane Diniz do Nascimento
Laboratório Adolpho Ducke, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Av. Perimetral, 1901, Terra Firme, Belem 66077-830, PA, Brazil
Celeste de Jesus Pereira Franco
Laboratório Adolpho Ducke, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Av. Perimetral, 1901, Terra Firme, Belem 66077-830, PA, Brazil
Oberdan Oliveira Ferreira
Laboratório Adolpho Ducke, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Av. Perimetral, 1901, Terra Firme, Belem 66077-830, PA, Brazil
Tainá Oliveira dos Anjos
Programa de Pós-Graduação em Botânica Tropical, Universidade Federal Rural da Amazônia, Avenida Tancredo Neves, 2501, Belem 66077-830, PA, Brazil
Himani Karakoti
Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar 263145, Uttarakhand, India
Ravendra Kumar
Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar 263145, Uttarakhand, India
Antônio Pedro da Silva Souza-Filho
Embrapa Amazônia Oriental, Av. Dr. Enéas Pinheiro, Marco, Belem 66095-903, PA, Brazil
Mozaniel Santana de Oliveira
Faculdade de Engenharia Química, Instituto de Tecnologia, Universidade Federal do Pará, Rua Augusto Corrêa, 01, Guamá, Belem 66075-900, PA, Brazil
Eloisa Helena de Aguiar Andrade
Faculdade de Engenharia Química, Instituto de Tecnologia, Universidade Federal do Pará, Rua Augusto Corrêa, 01, Guamá, Belem 66075-900, PA, Brazil
The essential oils (EOs) of Guatteria schomburgkiana (Gsch) and Xylopia frutescens (Xfru) (Annonaceae) were obtained by hydrodistillation, and their chemical composition was evaluated by gas chromatography-mass spectrometry (GC/MS). Herbicide activity was measured by analyzing the seed germination percentage and root and hypocotyl elongation of two invasive species: Mimosa pudica and Senna obtusifolia. The highest yield was obtained for the EO of Xfru (1.06%). The chemical composition of Gsch was characterized by the presence of the oxygenated sesquiterpenes spathulenol (22.40%) and caryophyllene oxide (14.70%). Regarding the EO of Xfru, the hydrocarbon monoterpenes α-pinene (35.73%) and β-pinene (18.90%) were the components identified with the highest concentrations. The germination of seeds of S. obtusifolia (13.33 ± 5.77%) showed higher resistance than that of seeds of M. pudica (86.67 ± 5.77%). S. obtusifolia was also more sensitive to the EO of Xfru in terms of radicle (55.22 ± 2.72%) and hypocotyl (71.12 ± 3.80%) elongation, while M. pudica showed greater sensitivity to the EO of Gsch. To screen the herbicidal activity, the molecular docking study of the major and potent compounds was performed against 4-hydroxyphenylpyruvate dioxygenase (HPPD) protein. Results showed good binding affinities and attributed the strongest inhibitory activity to δ-cadinene for the target protein. This work contributes to the study of the herbicidal properties of the EOs of species of Annonaceae from the Amazon region.
