Journal of Neurological Surgery Reports (Aug 2014)

Postsurgical Meningitis Complicated by Severe Refractory Intracranial Hypertension with Limited Treatment Options: The Role of Mild Therapeutic Hypothermia

  • Konstantin A. Popugaev,
  • Ivan A. Savin,
  • Andrew V. Oshorov,
  • Natalia V. Kurdumova,
  • Olga N. Ershova,
  • Andrew U. Lubnin,
  • Boris A. Kadashev,
  • Pavel L. Kalinin,
  • Maxim A. Kutin,
  • Tim Killeen,
  • Evaldas Cesnulis,
  • Ronald Melieste

DOI
https://doi.org/10.1055/s-0034-1387188
Journal volume & issue
Vol. 75, no. 02
pp. e224 – e229

Abstract

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Abstract Intracranial hypertension is a commonly encountered neurocritical care problem. If first-tier therapy is ineffective, second-tier therapy must be initiated. In many cases, the full arsenal of established treatment options is available. However, situations occasionally arise in which only a narrow range of options is available to neurointensivists. We present a rare clinical scenario in which therapeutic hypothermia was the only available method for controlling intracranial pressure and that demonstrates the efficacy and safety of the Thermogard (Zoll, Chelmsford, Massachusetts, United States) cooling system in creating and maintaining a prolonged hypothermic state. The lifesaving effect of hypothermia was overshadowed by the unfavorable neurologic outcome observed (minimally conscious state on intensive care unit discharge). These results add further evidence to support the role of therapeutic hypothermia in managing intracranial pressure and provide motivation for finding new strategies in combination with hypothermia to improve neurologic outcomes.

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