Molecules (Aug 2023)

Chemical Studies of Multicomponent Kidney Stones Using the Modern Advanced Research Methods

  • Weronika Sofińska-Chmiel,
  • Marta Goliszek,
  • Marek Drewniak,
  • Aldona Nowicka,
  • Marcin Kuśmierz,
  • Agnieszka Adamczuk,
  • Paulina Malinowska,
  • Ryszard Maciejewski,
  • Małgorzata Tatarczak-Michalewska,
  • Eliza Blicharska

DOI
https://doi.org/10.3390/molecules28166089
Journal volume & issue
Vol. 28, no. 16
p. 6089

Abstract

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Defining the kidney stone composition is important for determining a treatment plan, understanding etiology and preventing recurrence of nephrolithiasis, which is considered as a common, civilization disease and a serious worldwide medical problem. The aim of this study was to investigate the morphology and chemical composition of multicomponent kidney stones. The identification methods such as infrared spectroscopy (FTIR), X-ray diffraction (XRD), and electron microscopy with the EDX detector were presented. The studies by the X-ray photoelectron spectroscopy (XPS) were also carried out for better understanding of their chemical structure. The chemical mapping by the FTIR microscopy was performed to show the distribution of individual chemical compounds that constitute the building blocks of kidney stones. The use of modern research methods with a particular emphasis on the spectroscopic methods allowed for a thorough examination of the subject of nephrolithiasis.

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