Drug Design, Development and Therapy (Mar 2024)
Harmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors
Abstract
Souha H Youssef,1 Alka Garg,2 Yunmei Song,1 Nicole E Wylie,3 Sanjay Garg1 1Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia; 2SA Pharmacy, Women’s and Children’s Hospital, Adelaide, SA, Australia; 3Department of Paediatric Anaesthesia, Women’s and Children’s Hospital, Adelaide, SA, AustraliaCorrespondence: Sanjay Garg, University of South Australia, Adelaide, SA, 5000, Australia, Tel +618 8302 1575, Email [email protected]: Co-administering multiple intravenous (IV) agents via Y-connectors is a common practice in hospitalised and fasting surgical patients. However, there is a lack of reliable data confirming the physical compatibility of some combinations including IV oxycodone, a drug that is gaining increasing popularity in the perioperative period. Concern regarding physical drug incompatibilities precludes concurrent coadministration with other common drugs through a single lumen. This can result in the cessation of infusions to allow the administration of other medications, resulting in exacerbation of acute pain. This study aims to evaluate the physical compatibility of IV oxycodone with some commonly co-administered drugs and IV fluids.Methods: Mixtures of oxycodone (1mg.mL− 1) and the tested drugs and IV fluids were prepared in a ratio of 1:1. The mixtures were examined at 0 and 60 minutes from mixing and assessed using the European Conference Consensus Standards. This involved visual inspection (precipitation, turbidity, colour change, gas formation), spectrophotometry, and pH change. The tested drugs included ketamine, tramadol, clonidine, vancomycin, piperacillin/tazobactam, dexmedetomidine, cefotaxime, gentamicin, and paracetamol. In addition, the commonly used IV fluids tested included glucose 5% + sodium chloride 0.9% + 60 mmol potassium chloride, plasmalyte + dextrose 5%;plasmalyte + dextrose 5% + 55 mmol potassium chloride, plasmalyte + dextrose 5% + 55mmol potassium acetate, plasmalyte + dextrose 5% + 55mmol potassium dihydrogen phosphate, Hartmann’s solution, Standard pediatric Total Parenteral Nutrition (TPN) 20/100 and TPN 25/150.Results: IV oxycodone (1 mg.mL− 1) showed no visual changes; no spectrophotometric absorption variability at 350, 410, or 550nm; and no pH changes of > 0.5 at 0 or 60 minutes with any of the tested drugs or fluids in the concentrations tested.Conclusion: According to European Consensus Conference Standards, IV Oxycodone at 1 mg.mL− 1 is physically compatible in a ratio of 1:1 v/v with all investigated drugs and fluids tested for at least 60 minutes. Keywords: analgesia, physical compatibility, co-administration, intravenous fluid, oxycodone, Y-connector
