Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer

Hyun Mu Shin; Gwanghun Kim; Sangjib Kim; Ji Hyun Sim; Jiyeob Choi; Minji Kim; Minsuk Kwon; Sang-Kyu Ye; Dong-Sup Lee; Seung Woo Cho; Seung Tae Kim; Jeeyun Lee; Hang-Rae Kim

doi:10.1038/s41467-021-21299-w

Nature Communications (Feb 2021)

Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer

Hyun Mu Shin,
Gwanghun Kim,
Sangjib Kim,
Ji Hyun Sim,
Jiyeob Choi,
Minji Kim,
Minsuk Kwon,
Sang-Kyu Ye,
Dong-Sup Lee,
Seung Woo Cho,
Seung Tae Kim,
Jeeyun Lee,
Hang-Rae Kim

Affiliations

Hyun Mu Shin: Wide River Institute of Immunology, Seoul National University
Gwanghun Kim: Department of Biomedical Sciences, Seoul National University College of Medicine
Sangjib Kim: Department of Mathematics, College of Science, Korea University
Ji Hyun Sim: Department of Anatomy and Cell Biology, Seoul National University College of Medicine
Jiyeob Choi: Department of Biomedical Sciences, Seoul National University College of Medicine
Minji Kim: Department of Biomedical Sciences, Seoul National University College of Medicine
Minsuk Kwon: Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Sang-Kyu Ye: Department of Biomedical Sciences, Seoul National University College of Medicine
Dong-Sup Lee: Wide River Institute of Immunology, Seoul National University
Seung Woo Cho: Department of Biomedical Engineering, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)
Seung Tae Kim: Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Jeeyun Lee: Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Hang-Rae Kim: Wide River Institute of Immunology, Seoul National University

DOI: https://doi.org/10.1038/s41467-021-21299-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8+ T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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