Multi-species single-cell transcriptomic analysis of ocular compartment regulons

Pradeep Gautam; Kiyofumi Hamashima; Ying Chen; Yingying Zeng; Bar Makovoz; Bhav Harshad Parikh; Hsin Yee Lee; Katherine Anne Lau; Xinyi Su; Raymond C. B. Wong; Woon-Khiong Chan; Hu Li; Timothy A. Blenkinsop; Yuin-Han Loh

doi:10.1038/s41467-021-25968-8

Nature Communications (Sep 2021)

Multi-species single-cell transcriptomic analysis of ocular compartment regulons

Pradeep Gautam,
Kiyofumi Hamashima,
Ying Chen,
Yingying Zeng,
Bar Makovoz,
Bhav Harshad Parikh,
Hsin Yee Lee,
Katherine Anne Lau,
Xinyi Su,
Raymond C. B. Wong,
Woon-Khiong Chan,
Hu Li,
Timothy A. Blenkinsop,
Yuin-Han Loh

Affiliations

Pradeep Gautam: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology
Kiyofumi Hamashima: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology
Ying Chen: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology
Yingying Zeng: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology
Bar Makovoz: Icahn School of Medicine at Mount Sinai
Bhav Harshad Parikh: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
Hsin Yee Lee: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology
Katherine Anne Lau: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology
Xinyi Su: Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
Raymond C. B. Wong: Centre for Eye Research Australia
Woon-Khiong Chan: Department of Biological Sciences, National University of Singapore
Hu Li: Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic
Timothy A. Blenkinsop: Icahn School of Medicine at Mount Sinai
Yuin-Han Loh: Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology

DOI: https://doi.org/10.1038/s41467-021-25968-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

A comprehensive analysis of the ocular networks among various tissues is necessary to understand eye physiology in health and disease. Here the authors present a multi-species single-cell transcriptomic atlas consisting of cells of the cornea, iris, ciliary body, neural retina, retinal pigmented epithelium, and choroid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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